Sorry, no online dictionaries contain the exact phrase what is the matter.
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Reverse dictionary results:
1. issue
 2. problem
3. concern
4. trouble
5. difficulty
6. alarmedly
7. perplext
8. predicament
9. acrimoniously
10. aglee
 11. chasteningly
12. concerning
13. contumeliously
14. damningly
15. embarrassingly
16. fractious
17. furiously
18. hard time
19. hassle
20. how-d'ye-do
 21. importune
22. obnoxiously
23. offendedly
24. put off
25. quarrelsomely
26. rebarbatively
27. troble
28. troublesomely
29. troublously
30. abashedly
 31. aggravatingly
32. aggrievedly
33. anxiously
34. apprehensively
35. beseechingly
36. bother

You can look up the words in the phrase individually using these links:   what ?   is ?   the ?   matter ?
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