Usually means: Begin associating or engaging with.
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We found 11 dictionaries that define the word take up with:

General (9 matching dictionaries)
  1. take up with: Longman Dictionary of Contemporary English
  2. take up with: Merriam-Webster
  3. take up with: Oxford Learner's Dictionaries
  4. take up with: Collins English Dictionary
  5. take up with: Wiktionary
  6. take up with: Dictionary.com
  7. take up with: TheFreeDictionary.com

Business (1 matching dictionary)
  1. take up with: Merriam-Webster Legal Dictionary

Medicine (1 matching dictionary)
  1. take up with: Merriam-Webster Medical Dictionary

Definitions from Wiktionary (take up with)

verb:  To form a close relationship with (someone).
verb:  To become interested in (something).
verb:  To begin living together with; to lodge with.
verb:  (archaic) To be contented to receive; to receive without opposition; to put up with
verb:  Used other than figuratively or idiomatically: see take, up, take up, with.

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