Usually means: Assume control or go first.
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We found 6 dictionaries that define the word take the lead:

General (5 matching dictionaries)
  1. take the_lead: Merriam-Webster.com
  2. take the_lead: Wiktionary
  3. Take The Lead, Take the_Lead (Wanna Ride), Take the Lead, Take the lead: Wikipedia, the Free Encyclopedia

Business (1 matching dictionary)
  1. take the_lead: Legal dictionary

Definitions from Wiktionary (take the lead)

verb:  (idiomatic) To become the leader, to advance into first place.
verb:  (idiomatic) To assume leadership over a group.

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