Usually means: Nausea caused by space travel.
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We found 5 dictionaries that define the word spacesick:

General (3 matching dictionaries)
  1. spacesick: Wiktionary
  2. spacesick: Dictionary.com
  3. spacesick: TheFreeDictionary.com

Medicine (2 matching dictionaries)
  1. spacesick: Merriam-Webster Medical Dictionary
  2. spacesick: Medical dictionary

Definitions from Wiktionary (spacesick)

adjective:  Suffering from space sickness.

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