Usually means: Most acute, precise, or effective.
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We found 15 dictionaries that define the word sharpest:

General (10 matching dictionaries)
  1. sharpest: Merriam-Webster
  2. sharpest: Collins English Dictionary
  3. sharpest: Vocabulary.com
  4. Sharpest, sharpest: Wordnik
  5. sharpest: Cambridge Advanced Learner's Dictionary
  6. sharpest: Wiktionary
  7. sharpest: Dictionary.com
  8. sharpest: Cambridge Essential American English Dictionary
  9. sharpest: FreeDictionary.org
  10. sharpest: TheFreeDictionary.com

Business (1 matching dictionary)
  1. sharpest: Legal dictionary

Computing (1 matching dictionary)
  1. sharpest: Encyclopedia

Medicine (1 matching dictionary)
  1. sharpest: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. sharpest: Idioms

Slang (1 matching dictionary)
  1. sharpest: Urban Dictionary

(Note: See sharp as well.)

Definitions from Wiktionary (SHARP)

adjective:  Terminating in a point or edge, especially one that can cut or pierce easily; not dull, obtuse, or rounded.
adjective:  (colloquial) Intelligent.
adjective:  (music) Raised by one semitone (denoted by the symbol ♯ after the name of the note).
adjective:  (music) Higher in pitch than required.
adjective:  Having a strong acrid or acidic taste.
adjective:  Sudden, abrupt, intense, rapid.
adjective:  (colloquial) Illegal or dishonest.
adjective:  (colloquial) Keenly or unduly attentive to one's own interests; shrewd, verging on dishonest.
adjective:  Exact, precise, accurate; keen.
adjective:  Offensive, critical, or acrimonious; stern or harsh.
adjective:  (colloquial) Stylish, smart or attractive.
adjective:  Observant; alert; acute.
adjective:  Quick and alert.
adjective:  Strongly distinguishing or differentiating; acute.
adjective:  Forming a small or tight angle; especially, forming an angle of less than ninety degrees.
adjective:  Steep; precipitous; abrupt.
adjective:  (mathematics, of a statement) Said of as extreme a value as possible.
adjective:  (chess) Tactical; risky.
adjective:  Piercing; keen; severe; painful.
adjective:  Eager or keen in pursuit; impatient for gratification.
adjective:  (obsolete) Fierce; ardent; fiery; violent; impetuous.
adjective:  Composed of hard, angular grains; gritty.
adjective:  (phonetics, dated) Uttered in a whisper, or with the breath alone; aspirated; unvoiced.
adjective:  (obsolete) Hungry.
adverb:  In a sharp manner: a less usual alternative to sharply in certain senses.
adverb:  To a point or edge.
adverb:  Piercingly.
adverb:  Eagerly.
adverb:  So as to make a sharp, or tight, angle.
adverb:  (of times of day, not comparable) Exactly.
adverb:  (music) In a higher pitch than is correct or desirable.
noun:  (music) The symbol ♯, placed after the name of a note in the key signature or before a note on the staff to indicate that the note is to be played one chromatic semitone higher.
noun:  (music) A note that is played one chromatic semitone higher than usual; denoted by the name of the note that is followed by the symbol ♯.
noun:  (music) A note that is sharp in a particular key.
noun:  (music) The scale having a particular sharp note as its tonic.
noun:  (usually in the plural) Something that is sharp.
noun:  (medicine) A hypodermic syringe.
noun:  (medicine, dated) A scalpel or other edged instrument used in surgery.
noun:  (psychiatry, healthcare) A sharp object; any item pointed enough to injure human skin.
noun:  A dishonest person; a cheater.
noun:  Part of a stream where the water runs very rapidly.
noun:  A sewing needle with a very slender point, more pointed than a blunt or a between.
noun:  (in the plural) Fine particles of husk mixed with coarse particle of flour of cereals; middlings.
noun:  (slang, dated) An expert.
noun:  A sharpie (member of Australian gangs of the 1960s and 1970s).
verb:  (music) To raise the pitch of a note half a step making a natural note a sharp.
verb:  To play tricks in bargaining; to act the sharper.
verb:  (transitive, obsolete) To sharpen.
noun:  A surname.
noun:  A Japanese and Taiwanese multinational corporation that designs and manufactures electronic products, headquartered in Sakai, Japan.
noun:  An unincorporated community in Ozark County, Missouri, United States.
noun:  Alternative form of sharpie (“type of fishing boat”) [(colloquial) An alert person.]
noun:  Acronym of skinhead against racial prejudice.
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