Usually means: Mistake due to poor judgment.
Definitions Related words Mentions History
We found 13 dictionaries that define the word screwup:

General (12 matching dictionaries)
  1. screwup: Merriam-Webster
  2. screwup: Oxford Learner's Dictionaries
  3. screwup: American Heritage Dictionary of the English Language
  4. screwup: Vocabulary.com
  5. Screwup, screwup: Wordnik
  6. screwup: Wiktionary
  7. screwup: Infoplease Dictionary
  8. screwup: Dictionary.com
  9. screwup: Rhymezone
  10. screwup: FreeDictionary.org
  11. screwup: Mnemonic Dictionary
  12. screwup: TheFreeDictionary.com

Medicine (1 matching dictionary)
  1. screwup: Medical dictionary

(Note: See screwups as well.)

Definitions from Wiktionary (screwup)

noun:  (colloquial) A substantial mistake, usually causing problems for more people than just the person or group who made it.
noun:  (colloquial) A person who often makes substantial mistakes; a bungler.
noun:  (colloquial) A person who is mentally or emotionally damaged.

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