Usually means: Make a significant error or mistake.
Definitions Related words Phrases (New!) Mentions Colors (New!)
We found 23 dictionaries that define the word screw up:

General (16 matching dictionaries)
  1. screw up: Merriam-Webster.com
  2. screw up: Oxford Learner's Dictionaries
  3. screw-up, screw-up, screw up: Collins English Dictionary
  4. screw up: Vocabulary.com
  5. Screw-Up, Screw-up, screw-up: Wordnik
  6. screw (sth) up: Cambridge Advanced Learner's Dictionary
  7. screw-up, screw up: Wiktionary
  8. screw-up: Webster's New World College Dictionary, 4th Ed.
  9. screw-up, screw up: Dictionary.com
  10. Screw Up: Wikipedia, the Free Encyclopedia
  11. screw up: Rhymezone
  12. screw up: Free Dictionary
  13. screw up: Mnemonic Dictionary
  14. screw-up, screw up: Dictionary/thesaurus

Computing (1 matching dictionary)
  1. screw up: Encyclopedia

Medicine (1 matching dictionary)
  1. screw up: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. screw up: Idioms

Slang (4 matching dictionaries)
  1. screw up: Green’s Dictionary of Slang
  2. screw up: English slang and colloquialisms used in the United Kingdom
  3. screw-up, screw up: ESL Slang page
  4. Screw-Up, screw up: Urban Dictionary

(Note: See screw_ups as well.)

Definitions from Wiktionary (screw up)

verb:  (transitive) To tighten or secure with screws.
verb:  (transitive) To raise (rent, fees, etc.) to extortionate levels.
verb:  (transitive) To raise or summon up.
verb:  (transitive) To twist into a contorted state.
verb:  (transitive, dated) To squint.
verb:  (transitive, colloquial) To make a mess of; to ruin.
verb:  (intransitive, colloquial) To blunder; to make a mistake.

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