Usually means: Boosts mood or energy quickly.
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We found 4 dictionaries that define the word picker-upper:

General (4 matching dictionaries)
  1. picker-upper: Wordnik
  2. picker-upper: Wiktionary
  3. picker-upper: Infoplease Dictionary
  4. picker-upper: Dictionary.com

Definitions from Wiktionary (picker-upper)

noun:  (colloquial) A person who picks things up.
noun:  (colloquial) A tool used to pick things up.

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