Usually means: Mispronunciation of opioid painkiller OxyContin.
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We found 4 dictionaries that define the word oxycotton:

General (1 matching dictionary)
  1. oxycotton: Wiktionary

Medicine (1 matching dictionary)
  1. Oxycotton: Medical dictionary

Slang (2 matching dictionaries)
  1. Oxycotton: Street Terms: Drugs and the Drug Trade
  2. oxycotton: Urban Dictionary

Definitions from Wiktionary (oxycotton)

noun:  (slang) oxycodone used as a recreational drug

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