Sorry, no online dictionaries contain the exact phrase opposite of optimize.
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Reverse dictionary results:
1. retool
 2. alien
3. anti
4. bang
5. bid
6. bonnet
7. bow
8. box
9. boxy
10. cast
 11. casted
12. charge
13. charged
14. charging
15. clash
16. contradict
17. countermine
18. cut
19. difference
20. disinclined
 21. down
22. eagle
23. economic
24. exit
25. face
26. foot
27. foul
28. hit
29. hook
30. iff
 31. letter
32. lift
33. luft
34. mar
35. neutralize
36. nose
37. nox
38. oppose
39. opposing
40. pawn

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   optimize ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
oppo*to search for words beginning with oppo, or
*mizeto search for words ending with mize
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