Sorry, no online dictionaries contain the exact phrase opposite of in the main.
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Reverse dictionary results:
1. minority
2. subsidiary
3. secondary
4. subordinate
5. ancillary
6. collateral
7. ground rule
8. bye
9. complemental
10. presence
11. second-generation
12. adjunct
13. appurtenant
14. goal setting
15. majority rule
16. accompanying
17. adscription
18. agency
19. coedition
20. first thing
21. ground
22. outcome
23. participance
24. participation
25. participatory
26. primum mobile
27. principal
28. supplementary
29. suppletory
30. accessional
31. add'l
32. basic
33. coadjuvancy
34. complement
35. copresent
36. inception
37. institutionary
38. institutive

You can look up the words in the phrase individually using these links:   opposite ?   of ?   in ?   the ?   main ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
oppo*to search for words beginning with oppo, or
*mainto search for words ending with main
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