Sorry, no online dictionaries contain the exact phrase open it up.
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Reverse dictionary results:
1. enter
 2. name
3. talk
4. sky
5. lie
6. caftan
7. robe
8. sale
9. share
10. pioneer
 11. opening
12. expand
13. initiate
14. unroll
15. tab
16. awake
17. blast
18. burst
19. crack
20. disclose
 21. opened
22. opens
23. unclose
24. apex
25. genie
26. ink
27. groundbreaker
28. innovator
29. trailblazer
30. cut
 31. prepared
32. upping
33. ups
34. appropriate
35. begin
36. beginning
37. bloom
38. blossom
39. break
40. closed

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You can look up the words in the phrase individually using these links:   open ?   it ?   up ?
(A question mark next to a word above means that we couldn't find it, but clicking the word might provide spelling suggestions.)

Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
open*to search for words beginning with open, or
*t upto search for words ending with t up
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