Usually means: Reveal or express inner thoughts.
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We found 23 dictionaries that define the word open up:

General (15 matching dictionaries)
  1. open up: Merriam-Webster.com
  2. open up: Oxford Learner's Dictionaries
  3. open up: Collins English Dictionary
  4. open up: Vocabulary.com
  5. open-up: Wordnik
  6. open (sth) up, open up: Cambridge Advanced Learner's Dictionary
  7. open up: Wiktionary
  8. open up: Dictionary.com
  9. Open Up (Cog song), Open Up (Leftfield song), Open Up (Mungo Jerry song), Open Up: Wikipedia, the Free Encyclopedia
  10. open up: Rhymezone
  11. open up: Free Dictionary
  12. open up: Mnemonic Dictionary
  13. open up: Dictionary/thesaurus

Business (4 matching dictionaries)
  1. MoneyGlossary.com (No longer online)
  2. Open up: Bloomberg Financial Glossary
  3. Open Up (disambiguation), open up: Legal dictionary
  4. Open Up (disambiguation), Open up: Financial dictionary

Computing (1 matching dictionary)
  1. open up: Encyclopedia

Medicine (1 matching dictionary)
  1. open up: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. open up: Idioms

Slang (1 matching dictionary)
  1. open up: Urban Dictionary

Definitions from Wiktionary (open up)

verb:  (intransitive, transitive) To open.
verb:  (intransitive) To widen.
verb:  (intransitive) To reveal oneself; to share personal information about oneself; to become communicative.
verb:  (intransitive) To commence firing weapons.
verb:  (intransitive, figuratively, of the sky) To rain.
verb:  (intransitive) To begin running, driving, travelling, etc., at maximum speed.
verb:  (intransitive, theater) Synonym of cheat out (“to face or turn toward the audience more than would be natural”)
verb:  (intransitive, oenology) Of wine: to develop its full flavor a short time after being uncorked and poured.

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