Usually means: Involving multiple systems or organs.
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We found 6 dictionaries that define the word multisystemic:

General (4 matching dictionaries)
  1. multisystemic: American Heritage Dictionary of the English Language
  2. multisystemic: Wiktionary
  3. multisystemic: Dictionary.com
  4. multisystemic: TheFreeDictionary.com

Medicine (2 matching dictionaries)
  1. multisystemic: Merriam-Webster Medical Dictionary
  2. multisystemic: Medical dictionary

Definitions from Wiktionary (multisystemic)

adjective:  Of, pertaining to or affecting more than one system or organ of the body

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