Sorry, no online dictionaries contain the exact phrase most-significant digit.
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Reverse dictionary results:
1. dactyl
2. nine
3. numeral
4. one
5. thumb
6. toe
7. pinkie
8. area code
9. bastard wing
10. bit
11. byte
12. checksum
13. decimal digit
14. decimal place
15. digital
16. dinger
17. eight
18. exchanged
19. figure
20. finger
21. five
22. four
23. hallux
24. nail
25. niner
26. nought
27. number
28. octal digit
29. octal notation
30. opposable
31. period
32. positional notation
33. recur
34. repetend
35. seven
36. significant digit
37. six
38. ssn
39. three
40. thumbing

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You can look up the words in the phrase individually using these links:   most-significant ?   digit ?
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