Sorry, no online dictionaries contain the exact phrase most significant one bit.
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Reverse dictionary results:
1. more
2. mother
3. highest
4. main
5. paramount
6. top
7. greater
8. key
9. lead
10. right-hand
11. bigger
12. foremost
13. greatest
14. important
15. principal
16. lifework
17. best
18. ultimate
19. operative
20. worse
21. merest
22. face
23. major
24. anthropocentric
25. crucial
26. essential
27. higher
28. larger
29. largest
30. leading
31. primary
32. principale
33. prominent
34. senior
35. taller
36. wider
37. heartthrob
38. endian
39. antecedent
40. perform

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You can look up the words in the phrase individually using these links:   most ?   significant ?   one ?   bit ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
most*to search for words beginning with most, or
* bitto search for words ending with bit
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