Sorry, no online dictionaries contain the exact phrase mind-altering substance.
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Reverse dictionary results:
1. drug
 2. psychoactive substance
3. stimulant
4. hallucinogen
5. controlled substance
6. attachment
7. chemical restraint
8. coding
9. narcomania
10. pseudoaddiction
 11. withdrawal
12. dependence
13. withdrawal symptom
14. addictedness
15. antinarcotics
16. chemical dependency
17. controlled drug
18. counternarcotics
19. deaddiction
20. habit
 21. heroinism
22. narc
23. narco-state
24. narcology
25. narcoterrorism
26. narcoterrorist
27. narcotised
28. narcotism
29. narcotize
30. narcotraffic
 31. narcotrafficker
32. narcotrafficking
33. noxa
34. addiction
35. cocainism
36. cocainization
37. counterdrug
38. dependency

You can look up the words in the phrase individually using these links:   mind-altering ?   substance ?
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