Usually means: Powerful stimulant, similar to amphetamine.
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We found 20 dictionaries that define the word methedrine:

General (15 matching dictionaries)
  1. methedrine: Merriam-Webster
  2. Methedrine, methedrine: Oxford Learner's Dictionaries
  3. Methedrine: American Heritage Dictionary of the English Language
  4. methedrine: Collins English Dictionary
  5. Methedrine: Vocabulary.com
  6. methedrine: Wiktionary
  7. methedrine: Webster's New World College Dictionary, 4th Ed.
  8. Methedrine: Infoplease Dictionary
  9. methedrine: Dictionary.com
  10. Methedrine: Online Etymology Dictionary
  11. Methedrine: Wikipedia, the Free Encyclopedia
  12. Methedrine: Rhymezone
  13. methedrine: FreeDictionary.org
  14. methedrine: Mnemonic Dictionary
  15. Methedrine: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. methedrine: Encyclopedia

Medicine (2 matching dictionaries)
  1. methedrine: Merriam-Webster Medical Dictionary
  2. Methedrine: Medical dictionary

Slang (2 matching dictionaries)
  1. Methedrine: Street Terms: Drugs and the Drug Trade
  2. methedrine: Urban Dictionary

Definitions from Wiktionary (methedrine)

noun:  A brand name for methamphetamine.

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