Usually means: Interfere or tamper with something.
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We found 9 dictionaries that define the word mess with:

General (6 matching dictionaries)
  1. mess with: Merriam-Webster.com
  2. mess with: Oxford Learner's Dictionaries
  3. mess with: Wiktionary
  4. mess with: Dictionary.com

Miscellaneous (1 matching dictionary)
  1. mess with: Idioms

Slang (2 matching dictionaries)
  1. mess with: Green’s Dictionary of Slang
  2. mess with: Urban Dictionary

Definitions from Wiktionary (mess with)

verb:  (obsolete) To eat with.
verb:  (slang) To interfere with.
verb:  (slang) To diss; to put down.
verb:  (slang) To joke around with or dupe someone, in either a friendly or unfriendly manner.
verb:  (slang, especially African-American Vernacular) To admire, enjoy, or approve of.

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