Sorry, no online dictionaries contain the exact phrase make it ineffective.
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Reverse dictionary results:
1. negate
 2. neutralize
3. annul
4. neutralise
5. cancel
6. disable
7. overpower
8. stultify
9. vitiate
10. addle
 11. break
12. cancelled
13. deactivate
14. frustrate
15. jam
16. lame
17. neutralized
18. nullified
19. nullify
20. override
 21. paralyze
22. puncture
23. strike down
24. void
25. addled
26. hamstring
27. hamstrung
28. crush
29. break down
30. breakdown
 31. counter
32. counteract
33. crack
34. debugging
35. decapitate
36. pretense
37. neuter
38. junk
39. gag
40. gear

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You can look up the words in the phrase individually using these links:   make ?   it ?   ineffective ?
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