Usually means: Create positive change in society.
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We found 14 dictionaries that define the word make a difference:

General (10 matching dictionaries)
  1. make a difference: Merriam-Webster
  2. make a difference: Oxford Learner's Dictionaries
  3. make a difference: Collins English Dictionary
  4. make-a-difference: Wordnik
  5. make a (big) difference: Cambridge Advanced Learner's Dictionary
  6. make a difference: Wiktionary
  7. Make A Difference: Wikipedia, the Free Encyclopedia
  8. Make a Difference: TheFreeDictionary.com

Business (1 matching dictionary)
  1. Make a Difference: Legal dictionary

Computing (1 matching dictionary)
  1. Make a Difference: Encyclopedia

Medicine (1 matching dictionary)
  1. Make a Difference: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. make a difference: Idioms

Definitions from Wiktionary (make a difference)

verb:  (idiomatic, intransitive) To carry out an action, the result of which is a significant change, or an altered circumstance.
verb:  (idiomatic, intransitive) To be of importance; to matter.

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