Usually means: Significant, large-scale genetic mutation event.
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We found 7 dictionaries that define the word macromutation:

General (4 matching dictionaries)
  1. macromutation: Wiktionary
  2. macromutation: Infoplease Dictionary
  3. macromutation: Dictionary.com
  4. Macromutation: Wikipedia, the Free Encyclopedia

Computing (1 matching dictionary)
  1. macromutation: Encyclopedia

Medicine (1 matching dictionary)
  1. macromutation: Merriam-Webster Medical Dictionary

Science (1 matching dictionary)
  1. macromutation: Evolution Glossary

Definitions from Wiktionary (macromutation)

noun:  A large-scale mutation.

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