Usually means: Ruin or spoil something badly.
Definitions Related words Mentions
We found 15 dictionaries that define the word louse up:

General (12 matching dictionaries)
  1. louse up: Longman Dictionary of Contemporary English
  2. louse up: Merriam-Webster
  3. louse up: Vocabulary.com
  4. louse (sth) up: Cambridge Advanced Learner's Dictionary
  5. louse up: Wiktionary
  6. louse up: Dictionary.com
  7. louse up: Rhymezone
  8. louse up: FreeDictionary.org
  9. louse up: Mnemonic Dictionary
  10. louse up: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. louse up: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. louse up: Idioms

Slang (1 matching dictionary)
  1. louse up: Green’s Dictionary of Slang

Definitions from Wiktionary (louse up)

verb:  (idiomatic, colloquial) To mess up; to confuse; to put into a state of disorder.

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