Usually means: Miss opportunity, suffer disadvantageous consequences.
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We found 11 dictionaries that define the word lose out:

General (10 matching dictionaries)
  1. lose out: Merriam-Webster.com
  2. lose out: Oxford Learner's Dictionaries
  3. lose out: Collins English Dictionary
  4. lose-out: Wordnik
  5. lose out: Cambridge Advanced Learner's Dictionary
  6. lose out: Wiktionary
  7. lose out: Dictionary.com
  8. lose out: Dictionary/thesaurus

Miscellaneous (1 matching dictionary)
  1. lose out: Idioms

Definitions from Wiktionary (lose out)

verb:  To be at a disadvantage.
verb:  (with 'to') To be defeated (by).

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