Usually means: Start or begin an activity.
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We found 22 dictionaries that define the word lead off:

General (16 matching dictionaries)
  1. lead off: Merriam-Webster.com
  2. lead-off, lead off: Oxford Learner's Dictionaries
  3. lead-off, lead-off, lead off: Collins English Dictionary
  4. lead-off, lead off: Wiktionary
  5. lead-off: The Wordsmyth English Dictionary-Thesaurus
  6. lead-off: Infoplease Dictionary
  7. lead-off, lead off: Dictionary.com
  8. Lead off: Wikipedia, the Free Encyclopedia
  9. lead off: Rhymezone
  10. lead off: Free Dictionary
  11. lead off: Mnemonic Dictionary
  12. lead off: Dictionary/thesaurus
  13. lead off: Vocabulary.com
  14. lead-off: Wordnik

Business (2 matching dictionaries)
  1. lead off: Legal dictionary
  2. lead off: Financial dictionary

Computing (1 matching dictionary)
  1. lead off: Encyclopedia

Medicine (1 matching dictionary)
  1. lead off: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. lead off: Idioms

Slang (1 matching dictionary)
  1. lead off: Green’s Dictionary of Slang

Definitions from Wiktionary (lead off)

noun:  (baseball) The first batter in the batting order.
noun:  (baseball) The first batter of an inning.
noun:  (baseball) The short distance that a player stands away from their current base.
noun:  (broadcasting) The first item in a broadcast schedule.
verb:  Used other than figuratively or idiomatically: see lead, off.
verb:  (baseball) To be the first batter of an inning.
verb:  (by extension) To be the first of any set, especially the first person in a group to speak; to launch or begin something by speaking.

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