Usually means: Render unconscious or inoperative quickly.
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We found 21 dictionaries that define the word knock out:

General (13 matching dictionaries)
  1. knock out: Merriam-Webster.com
  2. knock out: Vocabulary.com
  3. Knock-Out, Knock-out, knock-out: Wordnik
  4. knock-out, knock out: Wiktionary
  5. Knock-out, knock-out, knock (oneself) out, knock out: Dictionary.com
  6. Knock Out (Bonfire album), Knock Out (Gottlieb pinball), Knock-out, Knock out: Wikipedia, the Free Encyclopedia
  7. knock out: Rhymezone
  8. knock out: Phrasal Verb Page
  9. knock-out, knock out: Free Dictionary
  10. knock out: Mnemonic Dictionary
  11. Knock-out, knock (oneself) out, knock out: Dictionary/thesaurus

Business (1 matching dictionary)
  1. knock out: Legal dictionary

Computing (1 matching dictionary)
  1. knock-out, knock out: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. knock out: Idioms

Science (1 matching dictionary)
  1. Knock-out: Cytokines & Cells Online Pathfinder Encyclopaedia

Slang (3 matching dictionaries)
  1. knock out: Green’s Dictionary of Slang
  2. knock out: English slang and colloquialisms used in the United Kingdom
  3. knock-out, knock out: Urban Dictionary

Tech (1 matching dictionary)
  1. Schlumberger Oilfield Glossary (No longer online)

(Note: See knock_outs as well.)

Definitions from Wiktionary (knock out)

verb:  To strike or render unconscious
verb:  (transitive) To strike or bump (someone or something) out.
verb:  (transitive, idiomatic) To render unconscious, as by a blow to the head.
verb:  (transitive, informal, idiomatic) To put to sleep.
verb:  (intransitive, informal, idiomatic) To fall asleep, especially suddenly.
verb:  (transitive, informal, idiomatic) To exhaust.
verb:  (transitive, informal, idiomatic) To impress, surpass or overwhelm (someone).
verb:  (transitive, slang) To defeat or kill (someone).
verb:  (transitive, idiomatic) To cause a mechanism to become non-functional by damaging or destroying it.
verb:  (transitive) To eliminate from a contest or similar.
verb:  (transitive) To communicate (a message) by knocking.
verb:  (transitive, informal) To complete, especially in haste; knock off.
verb:  To lose the scent of hounds in fox-hunting.
verb:  (obsolete, Oxford University slang) To leave college after hours—after half-past ten at night when the doors have been locked.
verb:  (transitive, Australia) To obtain or earn (something, often money or food).
verb:  (transitive, slang, UK) To sell.

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