Usually means: Six-layered cortex of the brain.
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We found 7 dictionaries that define the word isocortex:

General (2 matching dictionaries)
  1. isocortex: Wiktionary
  2. isocortex: Dictionary.com

Computing (1 matching dictionary)
  1. isocortex: Encyclopedia

Medicine (4 matching dictionaries)
  1. isocortex: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. online medical dictionary (No longer online)
  4. isocortex: Medical dictionary

Definitions from Wiktionary (isocortex)

noun:  (anatomy) The major part of the cerebral cortex

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