Might mean (unverified): Excessive addition of methyl groups.
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We found 2 dictionaries that define the word hypermethylation:

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  1. hypermethylation: Wordnik
  2. hypermethylation: Wiktionary

Definitions from Wiktionary (hypermethylation)

noun:  (genetics) an increase in the epigenetic methylation of cytosine and adenosine residues in DNA.

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