Sorry, no online dictionaries contain the exact phrase human-made region.
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Reverse dictionary results:
1. engineered
2. artificial
3. anthropogenic
4. contrived
5. human
6. man-made
7. manmade
8. -ric
9. -wide
10. aberdeen
11. abkhazia
12. aboriginal
13. aborigine
14. abruzzi
15. abundant
16. acadia
17. accent
18. account
19. achaea
20. acy
21. aden
22. aegean
23. aeolia
24. aeolis
25. aerospace
26. aetolia
27. afar
28. afghanistan
29. africa
30. african
31. africans
32. agra
33. ain
34. air
35. air hole
36. air pocket
37. airs
38. aisne
39. akkad
40. alagoas

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You can look up the words in the phrase individually using these links:   human-made ?   region ?
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