Usually means: Slang term for prescription opioids.
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We found 8 dictionaries that define the word hillbilly heroin:

General (2 matching dictionaries)
  1. hillbilly heroin: The Word Spy
  2. hillbilly heroin: Wiktionary

Business (1 matching dictionary)
  1. BuzzWhack (No longer online)

Computing (1 matching dictionary)
  1. hillbilly heroin: Netlingo

Medicine (1 matching dictionary)
  1. Hillbilly heroin: Medical dictionary

Slang (3 matching dictionaries)
  1. hillbilly heroin: Green’s Dictionary of Slang
  2. Hillbilly heroin: Street Terms: Drugs and the Drug Trade
  3. hillbilly heroin: Urban Dictionary

Definitions from Wiktionary (hillbilly heroin)

noun:  (US slang, derogatory) Oxycodone, Percocet, or similar opiate drugs, when used as recreational drugs.

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