Sorry, no online dictionaries contain the exact phrase have/keep one's guard up.
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Reverse dictionary results:
1. beware
 2. mind
3. halt
4. alert
5. defend
6. watch
7. aware
8. asleep
9. unwary
10. dandle
 11. mark
12. nose
13. stand
14. head
15. hold up
16. keep up
17. pecker
18. chin
19. uphilt
20. whistle
 21. ear
22. sell
23. abandon
24. adopt
25. blood
26. brace
27. dedicate
28. eye
29. hand
30. kick
 31. leg
32. neck
33. number
34. rally
35. surrender
36. wear
37. dander
38. defensive
39. self-sacrifice
40. wary

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You can look up the words in the phrase individually using these links:   have/keep ?   one's ?   guard ?   up ?
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