Sorry, no online dictionaries contain the exact phrase happen in a vacuum.
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Reverse dictionary results:
1. dall
 2. fall
3. falls
4. anything
5. chance
6. alternate
7. alternating
8. arise
9. avoid
10. break
 11. bring
12. bringing
13. case
14. causality
15. come
16. die
17. emerge
18. follow
19. get
20. give
 21. hope
22. hoping
23. let
24. lets
25. letting
26. mak
27. make
28. move
29. nix
30. play
 31. process
32. sort
33. strike
34. sure
35. turn
36. unfold
37. air
38. aspirator
39. condensation pump
40. cup

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You can look up the words in the phrase individually using these links:   happen ?   in ?   a ?   vacuum ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
happ*to search for words beginning with happ, or
*cuumto search for words ending with cuum
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