Usually means: Problem originating from the digestive system.
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We found 5 dictionaries that define the word gut issue:

General (5 matching dictionaries)
  1. gut issue: Vocabulary.com
  2. gut issue: Dictionary.com
  3. gut issue: FreeDictionary.org
  4. gut issue: Mnemonic Dictionary
  5. gut issue: TheFreeDictionary.com

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