Usually means: Explode, malfunction, or start talking.
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We found 23 dictionaries that define the word go off:

General (16 matching dictionaries)
  1. go off: Merriam-Webster.com
  2. go off: Oxford Learner's Dictionaries
  3. go off: Collins English Dictionary
  4. go-off: Wordnik
  5. go off: Cambridge Advanced Learner's Dictionary
  6. go-off, go off: Wiktionary
  7. go off: Dictionary.com
  8. Go Off, Go Off: Wikipedia, the Free Encyclopedia
  9. go off: Rhymezone
  10. go off: Free Dictionary
  11. go off: Mnemonic Dictionary
  12. go off: LookWAYup Translating Dictionary/Thesaurus
  13. go-off, go off: Dictionary/thesaurus
  14. go off: Vocabulary.com

Computing (1 matching dictionary)
  1. go off: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. AbbreviationZ (No longer online)

Slang (4 matching dictionaries)
  1. go off: Green’s Dictionary of Slang
  2. Totally Unofficial Rap (No longer online)
  3. American-Australian Slang Dictionary (No longer online)
  4. go off: Urban Dictionary

Tech (1 matching dictionary)
  1. AUTOMOTIVE TERMS (No longer online)

Definitions from Wiktionary (go off)

verb:  (intransitive) To explode.
verb:  (intransitive) To fire, especially accidentally.
verb:  (intransitive, figurative) To explode metaphorically; to become very angry.
verb:  (intransitive) To begin clanging or making noise.
verb:  (intransitive) To stop operating; to switch off.
verb:  (intransitive) To depart; to leave.
verb:  (intransitive, UK, Australia) To putrefy or become inedible, or to become unusable in any way.
verb:  (transitive) To like gradually less.
verb:  (intransitive, chiefly UK, of epoxy resins) To cure; to set.
verb:  (intransitive) To pass off; to take place; to be accomplished.
verb:  (slang) To ejaculate.
verb:  (LGBT, slang) Synonym of serve (“present an attractive personal appearance”)
verb:  (transitive) To follow or extrapolate from something; to judge by.

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Colors:
    red,     orange,     yellow,     neon green,     electric blue,     hot pink,     lime,     magenta,     crimson,     scarlet



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