Usually means: Falsely incriminate someone as guilty.
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We found 24 dictionaries that define the word frame up:

General (20 matching dictionaries)
  1. frame-up: Merriam-Webster
  2. frame-up: Oxford Learner's Dictionaries
  3. frame-up: American Heritage Dictionary of the English Language
  4. frame-up, frame-up: Collins English Dictionary
  5. frame-up, frame up: Vocabulary.com
  6. Frame-up, frame-up: Wordnik
  7. frame-up: Cambridge Advanced Learner's Dictionary
  8. frame-up, frame up: Wiktionary
  9. frame-up: Webster's New World College Dictionary, 4th Ed.
  10. frame-up: The Wordsmyth English Dictionary-Thesaurus
  11. frame-up: Infoplease Dictionary
  12. Frame-up, frame-up, frame up: Dictionary.com
  13. Frame Up, Frame-up, The Frame-Up: Wikipedia, the Free Encyclopedia
  14. frame-up, frame up: Rhymezone
  15. frame-up, frame up: FreeDictionary.org
  16. frame-up, frame up: Mnemonic Dictionary
  17. frame-up, frame up: TheFreeDictionary.com
  18. frame up: Longman Dictionary of Contemporary English

Business (2 matching dictionaries)
  1. Glossary of Legal Terms (No longer online)
  2. frame up: Legal dictionary

Computing (1 matching dictionary)
  1. frame-up, frame up: Encyclopedia

Slang (1 matching dictionary)
  1. frame up: Green’s Dictionary of Slang

(Note: See frame_ups as well.)

Definitions from Wiktionary (frame up)

verb:  (transitive, construction) To erect the initial walls and roof of (a new building).
verb:  (transitive) To arrange fraudulent evidence to falsely implicate (a person) of a crime.

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