Might mean (unverified): Ratio of final to initial values.
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We found one dictionary that defines the word foldchange:

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  1. foldchange: Wiktionary

Definitions from Wiktionary (foldchange)

noun:  (sciences) A measurement of change in value, expressed as a ratio, so that for example a value changing from 30 to 60 represents a foldchange of 2.

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