Usually means: Pain reliever for headaches, migraines.
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We found 4 dictionaries that define the word excedrin:

General (2 matching dictionaries)
  1. Excedrin: Wordnik
  2. Excedrin (brand), Excedrin: Wikipedia, the Free Encyclopedia

Medicine (2 matching dictionaries)
  1. Excedrin, Excedrin: Medical dictionary

Definitions from Wikipedia (Excedrin)

noun:  The brand became known for advertisements where it cured especially unpleasant and excruciating headaches (called "Excedrin headaches" in the ads of 1970s, and later called "Excedrin tension headaches").

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