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We found one dictionary with English definitions that includes the word down with dope up with hope:
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Slang (1 matching dictionary)

1. Up with Hope, Down with Dope: Urban Dictionary [home, info]

▸ Words similar to down with dope up with hope ▸ Usage examples for down with dope up with hope ▸ Idioms related to down with dope up with hope (New!) ▸ Words that often appear near down with dope up with hope ▸ Rhymes of down with dope up with hope ▸ Invented words related to down with dope up with hope