Usually means: Small, hardy horses of Northwest.
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We found 10 dictionaries that define the word cayuses:

General (8 matching dictionaries)
  1. Cayuses, cayuses: Merriam-Webster
  2. Cayuses: Oxford Learner's Dictionaries
  3. cayuses: Collins English Dictionary
  4. cayuses: Vocabulary.com
  5. Cayuses, cayuses: Wordnik
  6. cayuses: Wiktionary
  7. cayuses: Dictionary.com
  8. Cayuses: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Cayuses: Encyclopedia

Medicine (1 matching dictionary)
  1. Cayuses: Medical dictionary

(Note: See cayuse as well.)

Definitions from Wiktionary (Cayuse)

noun:  (US) A small Indian horse or pony.
noun:  A Native American tribe of Oregon.
▸ Also see cayuse


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