Usually means: Significant advancement beyond previous limitations.
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We found 35 dictionaries that define the word breakthrough:

General (22 matching dictionaries)
  1. breakthrough: Merriam-Webster.com
  2. breakthrough: Oxford Learner's Dictionaries
  3. breakthrough: American Heritage Dictionary of the English Language
  4. breakthrough: Collins English Dictionary
  5. breakthrough: Vocabulary.com
  6. Breakthrough, breakthrough: Wordnik
  7. breakthrough: Cambridge Advanced Learner's Dictionary
  8. breakthrough: Wiktionary
  9. breakthrough: Webster's New World College Dictionary, 4th Ed.
  10. breakthrough: The Wordsmyth English Dictionary-Thesaurus
  11. breakthrough: Infoplease Dictionary
  12. breakthrough: Dictionary.com
  13. breakthrough: Cambridge Essential American English Dictionary
  14. Breakthrough (Aya Hirano song), Breakthrough (Colbie Caillat album), Breakthrough (Dutch political history), Breakthrough (Lemonade Mouth song), Breakthrough (TV series), Breakthrough (The Gaslamp Killer album), Breakthrough (Twice song), Breakthrough (board game), Breakthrough (human rights), Breakthrough (military), Breakthrough, The Breakthrough: Wikipedia, the Free Encyclopedia
  15. breakthrough: Rhymezone
  16. breakthrough: AllWords.com Multi-Lingual Dictionary
  17. breakthrough: Free Dictionary
  18. breakthrough: Mnemonic Dictionary
  19. breakthrough: Dictionary/thesaurus
  20. breakthrough: Wikimedia Commons US English Pronunciations

Business (3 matching dictionaries)
  1. MoneyGlossary.com (No longer online)
  2. breakthrough: Financial dictionary
  3. BusinessDictionary.com (No longer online)

Computing (1 matching dictionary)
  1. breakthrough: Encyclopedia

Medicine (3 matching dictionaries)
  1. online medical dictionary (No longer online)
  2. Glossary of HIV/AIDS Related Terms (No longer online)
  3. breakthrough: Medical dictionary

Slang (1 matching dictionary)
  1. Breakthrough: Urban Dictionary

Sports (1 matching dictionary)
  1. Breakthrough: Chess Dictionary

Tech (4 matching dictionaries)
  1. Glossary of Coal Mining Terms (No longer online)
  2. Lake and Water Word Glossary (No longer online)
  3. Schlumberger Oilfield Glossary (No longer online)
  4. BREAKTHROUGH: Power Engineering

(Note: See breakthroughs as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
adjective:  Characterized by major progress or overcoming some obstacle.
adjective:  (immunology) Involving the contraction of a disease by a person with a decreased susceptibility, such as a person who has been vaccinated to help prevent that disease.
noun:  (military) An advance through and past enemy lines.
noun:  Any major progress; such as a great innovation or discovery that overcomes a significant obstacle.
noun:  (sports) The penetration of the opposition's defence.
noun:  (construction) The penetration of a separating wall or the remaining distance to an adjacent hollow (a crosscut in mining) or between two parts of a tunnel build from both ends; knockthrough.
noun:  (medicine, sometimes attributive) The emergence or one or more symptoms of a condition despite medication or other medical treatment.

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