Usually means: Additional dose enhancing vaccine effectiveness.
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We found 17 dictionaries that define the word booster shot:

General (11 matching dictionaries)
  1. booster shot: Merriam-Webster.com
  2. booster shot: American Heritage Dictionary of the English Language
  3. booster shot: Vocabulary.com
  4. booster shot: Wiktionary
  5. booster shot: The Wordsmyth English Dictionary-Thesaurus
  6. booster shot: Dictionary.com
  7. Booster shot: Wikipedia, the Free Encyclopedia
  8. booster shot: Rhymezone
  9. booster shot: Free Dictionary
  10. booster shot: Mnemonic Dictionary
  11. booster shot: Dictionary/thesaurus

Business (2 matching dictionaries)
  1. Booster Shot: Investopedia
  2. Booster Shot: Financial dictionary

Computing (1 matching dictionary)
  1. booster shot: Encyclopedia

Medicine (3 matching dictionaries)
  1. Booster shot: MedTerms.com Medical Dictionary
  2. booster shot: Medical dictionary
  3. Booster shot: Drug Medical Dictionary

(Note: See booster_shots as well.)

Definitions from Wiktionary (booster shot)

noun:  A dose of an antigen (usually a vaccine) designed to strengthen immunity after an earlier immunizing dose.

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