Usually means: Hybrid of domestic cattle, bison.
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We found 18 dictionaries that define the word beefalo:

General (16 matching dictionaries)
  1. beefalo: Merriam-Webster.com
  2. beefalo: Oxford Learner's Dictionaries
  3. beefalo: American Heritage Dictionary of the English Language
  4. beefalo: Collins English Dictionary
  5. beefalo: Vocabulary.com
  6. beefalo: Wordnik
  7. beefalo: Wiktionary
  8. beefalo: Webster's New World College Dictionary, 4th Ed.
  9. beefalo: The Wordsmyth English Dictionary-Thesaurus
  10. beefalo: Infoplease Dictionary
  11. beefalo: Dictionary.com
  12. Beefalo: Wikipedia, the Free Encyclopedia
  13. beefalo: Rhymezone
  14. beefalo: Free Dictionary
  15. beefalo: Mnemonic Dictionary
  16. beefalo: Dictionary/thesaurus

Medicine (1 matching dictionary)
  1. beefalo: Medical dictionary

Slang (1 matching dictionary)
  1. beefalo: Urban Dictionary

(Note: See beefaloes as well.)

Definitions from Wiktionary (beefalo)

noun:  A cross between a domestic cow and an American buffalo or bison.
noun:  The meat of such a hybrid.

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