Usually means: Molecule with both hydrophilic, hydrophobic parts.
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We found 9 dictionaries that define the word amphiphile:

General (6 matching dictionaries)
  1. amphiphile: Merriam-Webster
  2. amphiphile: Collins English Dictionary
  3. amphiphile: Wiktionary
  4. amphiphile: Infoplease Dictionary
  5. amphiphile: Dictionary.com
  6. Amphiphile: Wikipedia, the Free Encyclopedia

Computing (1 matching dictionary)
  1. amphiphile: Encyclopedia

Medicine (2 matching dictionaries)
  1. amphiphile: Merriam-Webster Medical Dictionary
  2. Amphiphile: Medical dictionary

(Note: See amphiphilic as well.)

Definitions from Wiktionary (amphiphile)

noun:  (chemistry) A chemical compound which has both hydrophilic and hydrophobic properties. Many such compounds are used as surfactants.

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