Usually means: Non-player character in games.
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We found 24 dictionaries that define the word NPC:

General (12 matching dictionaries)
  1. NPC: Merriam-Webster
  2. NPC: Collins English Dictionary
  3. NPC: Vocabulary.com
  4. npc: Wordnik
  5. NPC: Wiktionary
  6. NPC: Dictionary.com
  7. NPC (meme), NPC, Npc: Wikipedia, the Free Encyclopedia
  8. Npc: Rhymezone
  9. NPC: Stammtisch Beau Fleuve Acronyms
  10. npc: FreeDictionary.org
  11. npc: Mnemonic Dictionary
  12. NPC: TheFreeDictionary.com

Computing (4 matching dictionaries)
  1. NPC: Free On-line Dictionary of Computing
  2. NPC: Game Dictionary
  3. Webopedia (No longer online)
  4. NPC: Encyclopedia

Medicine (2 matching dictionaries)
  1. online medical dictionary (No longer online)
  2. NPC: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. NPC: Acronym Finder
  2. AbbreviationZ (No longer online)

Science (1 matching dictionary)
  1. Glossary of Genetic Terms (No longer online)

Sports (1 matching dictionary)
  1. NPC: Body Building

Tech (2 matching dictionaries)
  1. AUTOMOTIVE TERMS (No longer online)
  2. DOD Dictionary of Military Terms: Joint Acronyms and Abbreviations (No longer online)

(Note: See npcs as well.)

Definitions from Wiktionary (NPC)

noun:  (Internet slang, figuratively) A person with no ability to think for themselves; a sheeple (originally referring to opponents of former US President Donald Trump).
verb:  (intransitive) To act as an NPC (“non-player character”) in a game.
noun:  (roleplaying games, video games) Initialism of non-player character. [(roleplaying games, video games) A character in a role-playing game or computer game whose actions are not controlled by a player.]
noun:  (medicine, chiefly attributive) Initialism of no patient care.
noun:  (medicine) Initialism of Niemann-Pick disease type C.
noun:  (medicine) Initialism of nasopharyngeal carcinoma. [(pathology) A cancer originating in the nasopharynx, most commonly in the posterolateral aspect of the nasopharynx.]
noun:  (computing) Initialism of non-printing character. [Synonym of control character.]
noun:  (Singapore) Initialism of neighbourhood police center.
noun:  (Philippines) Initialism of National Power Corporation.
noun:  (Philippines) Initialism of National Privacy Commission.
noun:  (sports) Initialism of National Paralympic Committee.
noun:  (Philippine politics) Initialism of Nationalist People's Coalition.
noun:  (China) Initialism of National People's Congress.
noun:  (US) Initialism of National Physique Committee.
noun:  (US) Initialism of National Petroleum Council.
noun:  (Nigeria) Initialism of Northern People's Congress.
noun:  (New Zealand) Initialism of National Provincial Championship.

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