Usually means: Refusal or negative response expression.
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We found 28 dictionaries that define the word NOPE:

General (23 matching dictionaries)
  1. nope: Merriam-Webster.com
  2. nope: Oxford Learner's Dictionaries
  3. NOPE: The Word Spy
  4. nope: American Heritage Dictionary of the English Language
  5. nope: Collins English Dictionary
  6. Nope, nope: Wordnik
  7. nope: Cambridge Advanced Learner's Dictionary
  8. Nope, nope: Wiktionary
  9. nope: Webster's New World College Dictionary, 4th Ed.
  10. nope: The Wordsmyth English Dictionary-Thesaurus
  11. nope: Infoplease Dictionary
  12. NOPE: Dictionary.com
  13. nope: Online Etymology Dictionary
  14. nope: Cambridge Essential American English Dictionary
  15. Nope: Wikipedia, the Free Encyclopedia
  16. Nope: Online Plain Text English Dictionary
  17. nope: Webster's Revised Unabridged, 1913 Edition
  18. Nope: AllWords.com Multi-Lingual Dictionary
  19. nope: Webster's 1828 Dictionary
  20. nope: Free Dictionary
  21. nope: Dictionary/thesaurus

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Miscellaneous (2 matching dictionaries)
  1. NOPE: Acronym Finder
  2. AbbreviationZ (No longer online)

Slang (2 matching dictionaries)
  1. nope: Green’s Dictionary of Slang
  2. Nope: Urban Dictionary

Definitions from Wiktionary (Nope)

noun:  (informal) A negative reply, no.
noun:  (slang) An intensely undesirable thing, such as a circumstance or an animal, eliciting immediate repulsion without possibility of further consideration.
noun:  (archaic, except near Staffordshire) A bullfinch.
noun:  (East Midlands and Northern England) A blow to the head.
verb:  (archaic, East Midlands and Northern England) To hit someone on the head.
noun:  (archaic) Martha's Vineyard

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