Usually means: Wear out; exhaust physically, mentally.
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We found 12 dictionaries that define the word Fatigate:

General (12 matching dictionaries)
  1. fatigate: Merriam-Webster
  2. fatigate: Collins English Dictionary
  3. fatigate: Wordnik
  4. fatigate: Wiktionary
  5. Fatigate: Dictionary.com
  6. Fatigate: Online Plain Text English Dictionary
  7. fatigate: Webster's Revised Unabridged, 1913 Edition
  8. Fatigate: Rhymezone
  9. Fatigate: AllWords.com Multi-Lingual Dictionary
  10. fatigate: Webster's 1828 Dictionary
  11. fatigate: FreeDictionary.org
  12. Fatigate: TheFreeDictionary.com

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Definitions from Wiktionary (fatigate)

▸ verb:  (obsolete) To weary; to tire; to fatigue.
▸ adjective:  (obsolete) Wearied; tired; fatigued.

Similar:
defatigate, fatigue, tire out, wear, wilt, affatuate, wear out, tire, flag, fordo, more...

Opposite:
energize, invigorate, refresh, revitalize, stimulate

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Similar:
defatigate, fatigue, tire out, wear, wilt, affatuate, wear out, tire, flag, fordo, more...

Opposite:
energize, invigorate, refresh, revitalize, stimulate



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