Eugene Howard Spafford (born 1956), known as Spaf, is an American professor of computer science at Purdue University and a computer security expert.

Horatio Gates Spafford (October 20, 1828, Troy, New York – September 25, 1888, Jerusalem) was an American lawyer and Presbyterian church elder.

Anna Spafford (March 16, 1842 – April 17, 1923), born Anne Tobine Larsen Øglende in Stavanger, Norway, was a Norwegian-American woman who settled in Jerusalem, where she and her husband Horatio Spafford were central in establishing the American Colony there in 1881.