(March 10, 1810 – October 10, 1885) an American Catholic prelate who served as the first American-born Archbishop of New York from 1864 until his death in 1885, having previously served as Bishop of Albany.

John (September 15, 1914 – June 30, 2003) an American writer and illustrator of children's books.

Mark Thomas McCloskey is an American former personal injury lawyer practicing in St. Louis, Missouri, who attracted national attention in 2020 after he and his wife Patricia brandished firearms at protestors who walked past their house on a private street.

Deirdre Nansen McCloskey (born Donald Nansen McCloskey; September 11, 1942) is an American economist and academic.

Leigh Joseph McCloskey (born June 21, 1955) is an American actor, artist, author, and philosopher.

Paul Norton "Pete" McCloskey Jr. (September 29, 1927 – May 8, 2024) was an American politician who represented San Mateo County, California, as a Republican in the U.S. House of Representatives from 1967 to 1983.

John William McCloskey (September 19, 1925 – June 1, 2017) was an American basketball player, coach and executive.

Francis Xavier McCloskey (June 12, 1939 – November 2, 2003) was an American journalist, lawyer, and politician from Indiana who served in the United States House of Representatives as a Democrat from 1983 to 1995.