The Late Ordovician mass extinction, sometimes known as the end-Ordovician mass extinction or the Ordovician-Silurian extinction, is the first of the "big five" major mass extinction events in Earth's history, occurring roughly 445 million years ago (Ma).

The Capitanian mass extinction event, also known as the end-Guadalupian extinction event, the Guadalupian-Lopingian boundary mass extinction, the pre-Lopingian crisis, or the Middle Permian extinction, was an extinction event that predated the end-Permian extinction event.