Frank Octavius Mancuso (May 23, 1918 – August 4, 2007) was an American professional baseball player and, served as a Houston City Council member for 30 years after his sports career had ended.

Michael "The Nose" Mancuso (born July 18, 1955) is an American mobster.

Rodolfo Mancuso (born 1992) is an American Internet personality, musician and actor.

Nicodemo Antonio Massimo Mancuso (born May 29, 1948) is an Italian-Canadian actor, artist, playwright, and director.

(born 26 May 1992) an Italian professional footballer who plays as a forward or winger for club Mantova.

(born 22 November 1996) an Italian jazz and rock guitarist and composer from Palermo, Sicily.

David Paul Mancuso (October 20, 1944 – November 14, 2016) was an American disc jockey who created the popular "by invitation only" parties in New York City, which later became known as "The Loft".

Gail Susan Mancuso (born July 14, 1958birth check per intelius.com) is an American film and television director.

Frank G. Mancuso Jr. (born October 9, 1958) is an American film producer.

a clan of the 'Ndrangheta, a criminal and mafia-type organisation in Calabria, Italy.